Motif ID: TLX1..3_NFIC{dimer}.p2

Z-value: 3.453


Transcription factors associated with TLX1..3_NFIC{dimer}.p2:

Gene SymbolEntrez IDGene Name
TLX1 3195 T-cell leukemia homeobox 1
TLX3 30012 T-cell leukemia homeobox 3



Activity profile for motif TLX1..3_NFIC{dimer}.p2.

activity profile for motif TLX1..3_NFIC{dimer}.p2


Sorted Z-values histogram for motif TLX1..3_NFIC{dimer}.p2

Sorted Z-values for motif TLX1..3_NFIC{dimer}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TLX1..3_NFIC{dimer}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_+_38481392 5.935 NM_182801
EGFLAM
EGF-like, fibronectin type III and laminin G domains
chr2_-_192420168 5.598 NM_004657
SDPR
serum deprivation response
chr2_-_192419896 5.375 SDPR
serum deprivation response
chr15_-_38420414 4.738 NM_207380
C15orf52
chromosome 15 open reading frame 52
chr22_-_22970850 4.165 NM_001099781
NM_001099782
NM_004121
GGT5


gamma-glutamyltransferase 5


chr1_-_149611768 4.150 NM_003944
SELENBP1
selenium binding protein 1
chr17_-_74487527 4.083 NM_005567
LGALS3BP
lectin, galactoside-binding, soluble, 3 binding protein
chr14_+_23937766 3.876 NM_025081
NYNRIN
NYN domain and retroviral integrase containing
chr5_+_150000394 3.817 NM_001109974
NM_007286
SYNPO

synaptopodin

chr8_-_13178327 3.779


chr20_+_8997660 3.722 NM_001172646
PLCB4
phospholipase C, beta 4
chr20_+_8997791 3.677 PLCB4
phospholipase C, beta 4
chr22_+_40093245 3.536 NM_001145398
TEF
thyrotrophic embryonic factor
chr2_-_217268492 3.337 NM_000599
IGFBP5
insulin-like growth factor binding protein 5
chr17_-_74432671 3.318 TIMP2
TIMP metallopeptidase inhibitor 2
chr1_+_159435728 3.297 NM_004550
NDUFS2
NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)
chr7_+_102340579 3.248 NM_001031692
NM_005824
LRRC17

leucine rich repeat containing 17

chr19_-_8581559 3.221 NM_030957
ADAMTS10
ADAM metallopeptidase with thrombospondin type 1 motif, 10
chr19_+_15612706 3.198 NM_000896
CYP4F3
cytochrome P450, family 4, subfamily F, polypeptide 3
chr11_-_118716736 3.011 C1QTNF5
MFRP
C1q and tumor necrosis factor related protein 5
membrane frizzled-related protein
chr20_+_55569542 2.996 NM_002591
PCK1
phosphoenolpyruvate carboxykinase 1 (soluble)
chr1_-_159435440 2.984 NM_005099
ADAMTS4
ADAM metallopeptidase with thrombospondin type 1 motif, 4
chrX_+_99785818 2.980 NM_014467
SRPX2
sushi-repeat containing protein, X-linked 2
chr8_-_27524744 2.940 NM_203339
CLU
clusterin
chr20_+_34206070 2.937 NM_012156
EPB41L1
erythrocyte membrane protein band 4.1-like 1
chr21_+_32706615 2.869 NM_058187
C21orf63
chromosome 21 open reading frame 63
chr15_-_32875040 2.867 NM_005159
ACTC1
actin, alpha, cardiac muscle 1
chrX_-_53327473 2.857 NM_015075
IQSEC2
IQ motif and Sec7 domain 2
chr1_-_245342150 2.824 NM_207401
C1orf229
chromosome 1 open reading frame 229
chr14_+_85066207 2.816 NM_013231
FLRT2
fibronectin leucine rich transmembrane protein 2
chr12_+_56406296 2.806 LOC100130776
hypothetical LOC100130776
chr1_-_16217025 2.745 HSPB7
heat shock 27kDa protein family, member 7 (cardiovascular)
chr6_+_39868770 2.726 NM_015345
DAAM2
dishevelled associated activator of morphogenesis 2
chr15_+_76889873 2.673 MORF4L1
mortality factor 4 like 1
chr2_-_218551786 2.661 TNS1
tensin 1
chr14_+_85066265 2.656 FLRT2
fibronectin leucine rich transmembrane protein 2
chr9_+_27099138 2.626 NM_000459
TEK
TEK tyrosine kinase, endothelial
chr1_-_39180036 2.564 NM_017821
RHBDL2
rhomboid, veinlet-like 2 (Drosophila)
chr1_-_159459814 2.559 APOA2
apolipoprotein A-II
chr1_-_159459999 2.531 NM_001643
APOA2
apolipoprotein A-II
chr21_-_27139563 2.525 NM_006988
ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr12_+_118100977 2.512 NM_014365
HSPB8
heat shock 22kDa protein 8
chr10_+_685887 2.498 C10orf108
chromosome 10 open reading frame 108
chr17_-_74433048 2.455 NM_003255
TIMP2
TIMP metallopeptidase inhibitor 2
chr9_+_135389698 2.453 NM_014694
ADAMTSL2
ADAMTS-like 2
chr17_-_74432800 2.447 TIMP2
TIMP metallopeptidase inhibitor 2
chr21_-_27139143 2.445 ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr5_+_176449156 2.418 NM_022963
FGFR4
fibroblast growth factor receptor 4
chr3_-_11585264 2.411 NM_001128221
VGLL4
vestigial like 4 (Drosophila)
chr10_-_100164877 2.382 NM_032709
PYROXD2
pyridine nucleotide-disulphide oxidoreductase domain 2
chr8_-_27525084 2.371 NM_001171138
CLU
clusterin
chr1_+_61319976 2.360 NM_001145512
NFIA
nuclear factor I/A
chr7_-_99411573 2.359 NM_001185
AZGP1
alpha-2-glycoprotein 1, zinc-binding
chr16_-_49742651 2.358 NM_002968
SALL1
sal-like 1 (Drosophila)
chr15_-_66511488 2.324 NM_001004439
ITGA11
integrin, alpha 11
chr16_-_30032330 2.319 NM_024307
GDPD3
glycerophosphodiester phosphodiesterase domain containing 3
chr11_-_85074848 2.293 NM_152723
CCDC89
coiled-coil domain containing 89
chr15_-_38417564 2.292 C15orf52
chromosome 15 open reading frame 52
chr4_-_66218777 2.279 EPHA5
EPH receptor A5
chr12_+_64504408 2.278 NM_003483
NM_003484
HMGA2

high mobility group AT-hook 2

chr6_+_132170847 2.256 NM_006208
ENPP1
ectonucleotide pyrophosphatase/phosphodiesterase 1
chr1_-_151852128 2.236 NM_080388
S100A16
S100 calcium binding protein A16
chr11_-_62213577 2.224 LRRN4CL
LRRN4 C-terminal like
chr19_+_40322231 2.223 NM_005031
FXYD1
FXYD domain containing ion transport regulator 1
chr1_+_238321794 2.158 NM_020066
FMN2
formin 2
chr2_-_233586145 2.115 NGEF
neuronal guanine nucleotide exchange factor
chr1_-_27113018 2.096 NM_021969
NR0B2
nuclear receptor subfamily 0, group B, member 2
chr6_+_132170888 2.074 ENPP1
ectonucleotide pyrophosphatase/phosphodiesterase 1
chr11_-_2116048 2.067 IGF2
insulin-like growth factor 2 (somatomedin A)
chr2_-_233586164 2.065 NM_019850
NGEF
neuronal guanine nucleotide exchange factor
chr1_+_219026661 2.056 NM_022746
MOSC1
MOCO sulphurase C-terminal domain containing 1
chr2_+_66516196 2.053 MEIS1
Meis homeobox 1
chr11_+_74539679 2.039 NM_001145212
NM_007256
SLCO2B1

solute carrier organic anion transporter family, member 2B1

chr7_-_100077072 2.030 NM_003227
TFR2
transferrin receptor 2
chr3_+_8750485 2.021 NM_033337
NM_001234
CAV3

caveolin 3

chr19_+_3659358 2.007 TJP3
tight junction protein 3 (zona occludens 3)
chr1_-_171441234 2.003 TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr18_-_53621277 2.001 NM_005603
ATP8B1
ATPase, aminophospholipid transporter, class I, type 8B, member 1
chr22_-_37970902 1.971 NM_002608
PDGFB
platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)
chr8_-_42184194 1.961 PLAT
plasminogen activator, tissue
chr11_-_65082705 1.961 LTBP3
latent transforming growth factor beta binding protein 3
chr16_+_2025922 1.910 SLC9A3R2
solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2
chr6_-_31853027 1.909 NM_025258
C6orf27
chromosome 6 open reading frame 27
chr2_-_219404755 1.898 NM_017431
PRKAG3
protein kinase, AMP-activated, gamma 3 non-catalytic subunit
chr16_+_620932 1.892 NM_053284
WFIKKN1
WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1
chr1_-_151866593 1.853 NM_001024211
S100A13
S100 calcium binding protein A13
chr8_-_42184350 1.850 NM_000930
NM_033011
PLAT

plasminogen activator, tissue

chr1_+_151867483 1.839 NM_006271
S100A1
S100 calcium binding protein A1
chr12_-_50871953 1.819 NM_001081492
NM_182507
KRT80

keratin 80

chr20_+_43468046 1.812 NM_001197139
NM_001048221
NM_001048222
NM_001197140
NM_018478
DBNDD2




dysbindin (dystrobrevin binding protein 1) domain containing 2




chr17_+_24394281 1.793 PIPOX
pipecolic acid oxidase
chr3_-_12175339 1.771 TIMP4
TIMP metallopeptidase inhibitor 4
chr1_-_151867338 1.734 NM_005979
S100A13
S100 calcium binding protein A13
chrX_+_2756810 1.725 NM_001079855
NM_001184702
NM_001184703
NM_001184704
NM_003918
GYG2




glycogenin 2




chr20_-_33489383 1.700 NM_000557
GDF5
growth differentiation factor 5
chr20_-_5982617 1.691 NM_152611
LRRN4
leucine rich repeat neuronal 4
chr17_-_39265965 1.680 NM_001932
MPP3
membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
chr12_-_120781002 1.670 NM_002150
HPD
4-hydroxyphenylpyruvate dioxygenase
chr1_+_183970093 1.669 NM_031935
HMCN1
hemicentin 1
chr11_-_65082208 1.661 NM_001130144
NM_001164266
NM_021070
LTBP3


latent transforming growth factor beta binding protein 3


chr1_-_218168548 1.648 NM_018713
SLC30A10
solute carrier family 30, member 10
chr9_+_115396020 1.621 NM_144489
RGS3
regulator of G-protein signaling 3
chr10_+_135010833 1.613 NM_001145201
NM_145202
PRAP1

proline-rich acidic protein 1

chr9_-_78710698 1.611 NM_015225
PRUNE2
prune homolog 2 (Drosophila)
chr15_-_88159061 1.606 NM_001150
ANPEP
alanyl (membrane) aminopeptidase
chrX_+_99786044 1.595 SRPX2
sushi-repeat containing protein, X-linked 2
chr1_+_31659246 1.593 NM_001199039
NM_018565
SERINC2

serine incorporator 2

chr2_+_223244606 1.591 NM_058165
MOGAT1
monoacylglycerol O-acyltransferase 1
chr7_+_22733626 1.591 IL6
interleukin 6 (interferon, beta 2)
chr2_+_185171337 1.584 NM_194250
ZNF804A
zinc finger protein 804A
chrX_+_46822751 1.580 RGN
regucalcin (senescence marker protein-30)
chr21_+_45699830 1.568 NM_030582
NM_130444
COL18A1

collagen, type XVIII, alpha 1

chr12_+_55808696 1.566 LRP1
low density lipoprotein receptor-related protein 1
chr4_+_86968069 1.559 ARHGAP24
Rho GTPase activating protein 24
chrX_-_128616594 1.552 NM_017413
APLN
apelin
chrX_-_132947141 1.546 GPC3
glypican 3
chr9_-_8723893 1.545 NM_001040712
NM_001171025
NM_130391
NM_130392
NM_130393
PTPRD




protein tyrosine phosphatase, receptor type, D




chr18_-_5882102 1.542 NM_001080209
TMEM200C
transmembrane protein 200C
chr14_-_22515725 1.512 JUB
jub, ajuba homolog (Xenopus laevis)
chr16_-_51139214 1.510 NM_001146188
TOX3
TOX high mobility group box family member 3
chr10_-_49993425 1.491 NM_001031746
NM_144984
C10orf72

chromosome 10 open reading frame 72

chr17_+_75507750 1.485


chr14_+_94117545 1.468 SERPINA5
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
chr11_-_62213946 1.467 NM_203422
LRRN4CL
LRRN4 C-terminal like
chr11_-_64520964 1.437 NM_138456
BATF2
basic leucine zipper transcription factor, ATF-like 2
chrX_+_46822688 1.434 NM_004683
NM_152869
RGN

regucalcin (senescence marker protein-30)

chr19_+_15644885 1.434 NM_023944
CYP4F12
cytochrome P450, family 4, subfamily F, polypeptide 12
chrX_-_132947290 1.433 NM_001164617
NM_001164618
NM_001164619
NM_004484
GPC3



glypican 3



chr2_+_242400702 1.431 NM_001167599
NM_001167602
NM_080741
NEU4


sialidase 4


chr4_-_977163 1.430 NM_022042
NM_134425
NM_213613
SLC26A1


solute carrier family 26 (sulfate transporter), member 1


chr17_-_44226595 1.428 NM_173623
TTLL6
tubulin tyrosine ligase-like family, member 6
chr17_-_3129017 1.427 NM_002551
OR3A2
olfactory receptor, family 3, subfamily A, member 2
chr3_-_52463070 1.418 NM_003280
TNNC1
troponin C type 1 (slow)
chr5_-_148738980 1.413 NM_014443
IL17B
interleukin 17B
chr2_-_228290942 1.410 NM_025243
SLC19A3
solute carrier family 19, member 3
chr8_-_13178399 1.396 DLC1
deleted in liver cancer 1
chr14_-_21074875 1.395 NM_005407
SALL2
sal-like 2 (Drosophila)
chr9_+_139241838 1.384 NM_001190228
LOC643596
hypothetical LOC643596
chr22_+_43451351 1.359 NM_001017530
NM_001198721
NM_015366
PRR5


proline rich 5 (renal)


chr1_-_32940850 1.345 SYNC
syncoilin, intermediate filament protein
chr21_+_44761927 1.340 C21orf90
chromosome 21 open reading frame 90
chr8_-_143864933 1.327 NM_003695
LY6D
lymphocyte antigen 6 complex, locus D
chr2_+_233961538 1.315 NM_003648
DGKD
diacylglycerol kinase, delta 130kDa
chr11_-_10672079 1.311 NM_001100163
NM_130385
MRVI1

murine retrovirus integration site 1 homolog

chr9_-_25668855 1.308 NM_001004125
TUSC1
tumor suppressor candidate 1
chr7_+_22733290 1.303 NM_000600
IL6
interleukin 6 (interferon, beta 2)
chr10_+_82163568 1.290 C10orf58
chromosome 10 open reading frame 58
chr17_+_24394043 1.287 NM_016518
PIPOX
pipecolic acid oxidase
chr21_+_36993302 1.283


chr17_+_71065478 1.261 LLGL2
lethal giant larvae homolog 2 (Drosophila)
chr11_-_65081967 1.252 LTBP3
latent transforming growth factor beta binding protein 3
chr1_-_32054164 1.245 NM_144569
SPOCD1
SPOC domain containing 1
chr19_+_51493486 1.240 NM_022462
HIF3A
hypoxia inducible factor 3, alpha subunit
chr5_-_138746917 1.240 NM_005847
NM_152685
SLC23A1

solute carrier family 23 (nucleobase transporters), member 1

chr6_-_138935359 1.234 NM_020464
NHSL1
NHS-like 1
chr19_+_50004134 1.230 NM_001013257
NM_005581
BCAM

basal cell adhesion molecule (Lutheran blood group)

chr12_+_99391681 1.227 NM_005123
NR1H4
nuclear receptor subfamily 1, group H, member 4
chr3_+_171621721 1.217 NM_001185056
CLDN11
claudin 11
chr16_-_19803606 1.216 NM_016235
GPRC5B
G protein-coupled receptor, family C, group 5, member B
chr6_-_28429950 1.214 NM_145909
ZNF323
zinc finger protein 323
chr12_+_99391870 1.213 NR1H4
nuclear receptor subfamily 1, group H, member 4
chr3_-_12175646 1.212 NM_003256
TIMP4
TIMP metallopeptidase inhibitor 4
chr10_+_11905316 1.207 NM_153256
C10orf47
chromosome 10 open reading frame 47
chr12_+_123339662 1.205 NM_181709
FAM101A
family with sequence similarity 101, member A
chr16_+_55963899 1.194 NM_002996
CX3CL1
chemokine (C-X3-C motif) ligand 1
chr2_+_96818048 1.189 CNNM4
cyclin M4
chr3_-_197103848 1.181 TNK2
tyrosine kinase, non-receptor, 2
chr1_-_32036802 1.178 SPOCD1
SPOC domain containing 1
chr9_-_129679760 1.174 NM_000476
AK1
adenylate kinase 1
chr5_-_138746840 1.171 SLC23A1
solute carrier family 23 (nucleobase transporters), member 1
chr1_-_23683214 1.168 ASAP3
ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
chr6_-_53121540 1.168 NM_003643
GCM1
glial cells missing homolog 1 (Drosophila)
chr3_-_198784590 1.167 NM_203315
BDH1
3-hydroxybutyrate dehydrogenase, type 1
chr6_-_35804337 1.167 NM_001145775
FKBP5
FK506 binding protein 5
chr9_+_138991835 1.164 PTGDS
prostaglandin D2 synthase 21kDa (brain)
chr22_-_29866339 1.159 NM_015715
PLA2G3
phospholipase A2, group III
chr9_+_130719034 1.151 LRRC8A
leucine rich repeat containing 8 family, member A
chr6_-_30151526 1.138 NM_170769
NM_025236
RNF39

ring finger protein 39

chr16_-_28457825 1.136 NM_001042483
NM_012385
NUPR1

nuclear protein, transcriptional regulator, 1

chr11_+_77452550 1.134 NM_003251
THRSP
thyroid hormone responsive
chr5_-_54317102 1.133 NM_001135604
NM_007036
ESM1

endothelial cell-specific molecule 1

chr20_+_42417752 1.133 NM_001030003
NM_001030004
NM_175914
HNF4A


hepatocyte nuclear factor 4, alpha


chr1_-_151866367 1.129 NM_001024212
S100A13
S100 calcium binding protein A13
chr1_+_1836125 1.123 NM_138705
CALML6
calmodulin-like 6
chr20_-_60375695 1.114 NM_005560
LAMA5
laminin, alpha 5
chr2_-_74588293 1.114 NM_032673
PCGF1
polycomb group ring finger 1
chr2_-_216008689 1.109 FN1
fibronectin 1
chr2_+_28971007 1.104 NM_015131
WDR43
WD repeat domain 43
chr2_-_74588006 1.103 PCGF1
polycomb group ring finger 1
chr14_-_75516988 1.096 TGFB3
transforming growth factor, beta 3
chr7_-_123460722 1.080 NM_001136002
TMEM229A
transmembrane protein 229A
chrX_+_153423652 1.071 NM_001099856
IKBKG
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
chr17_-_59817722 1.070 NM_000442
PECAM1
platelet/endothelial cell adhesion molecule
chr2_+_66516020 1.070 NM_002398
MEIS1
Meis homeobox 1
chr7_-_5429702 1.069 NM_001080495
TNRC18
trinucleotide repeat containing 18
chr16_+_65783571 1.066 E2F4
E2F transcription factor 4, p107/p130-binding
chr1_-_32036858 1.064 SPOCD1
SPOC domain containing 1
chr5_+_135293889 1.061 NM_012159
FBXL21
F-box and leucine-rich repeat protein 21 (gene/pseudogene)
chr1_+_93830106 1.055 LOC100129046
hypothetical LOC100129046
chr14_-_93859394 1.055 NM_001756
SERPINA6
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
4.47 1.87e-02 GO:0032012 regulation of ARF protein signal transduction

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.63 3.27e-04 GO:0044421 extracellular region part
1.39 1.24e-03 GO:0005576 extracellular region
1.95 5.68e-03 GO:0031012 extracellular matrix
1.34 9.55e-03 GO:0044459 plasma membrane part
2.00 1.31e-02 GO:0005578 proteinaceous extracellular matrix
1.44 2.99e-02 GO:0031226 intrinsic to plasma membrane
2.28 3.48e-02 GO:0044297 cell body
1.84 3.56e-02 GO:0009986 cell surface

Nothing significant found in function category.